Tumor–Macrophage–Nerve interactions drive neuroinflammation and neuropathic pain in prostate cancer perineural invasion
This model provides insight into neuroinflammatory tumor-macrophage-nerve interactions associated with neuronal hyperexcitability. Although focused in scope, it enables stepwise investigation of tumor-induced neuronal responses and offers a useful platform for evaluating neuroinflammatory mechanisms of tumor invasion and for identifying potential therapeutic targets.
Authors
- Mohammed Shaqura (ORCID: https://orcid.org/0000-0002-4289-2188)
- Sascha Treskatsch (ORCID: https://orcid.org/0000-0002-0549-7680)
- Doaa M. Mohamed (ORCID: https://orcid.org/0000-0003-1144-3184)
- Susanne M. Krug (ORCID: https://orcid.org/0000-0002-1293-2484)
- Assaf Chalid
- Michael Schäfer
- Xueqi Hong
- Elsayed Y. Metwally
- Shaaban A. Mousa
Institutions
- Humboldt-Universität zu Berlin (DE)
- Helios Klinikum Krefeld (DE)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- Brain Behavior and Immunity
- Published
- 2026-01-13
- DOI
- https://doi.org/10.1016/j.bbi.2026.106280
- Primary Topic
- Cancer, Stress, Anesthesia, and Immune Response
- Type
- article
- Field-Weighted Citation Impact
- 0.00