Hepatic loss of AATF attenuates MASH by suppressing AKT–mTORC1 signaling and reprogramming lipid metabolism

Our findings reveal a previously unrecognized role of AATF as a central regulator of hepatic lipid metabolism in MASH, acting through the AKT-mTORC1 signaling pathway, and establish its inhibition as a promising therapeutic strategy for the treatment of metabolic liver disease.

Authors

Diwakar Suresh
Divya P. Kumar (ORCID: https://orcid.org/0000-0001-5935-379X)
Akshatha N. Srinivas (ORCID: https://orcid.org/0000-0001-5524-2312)
Gopalkrishna Ramaswamy
Divya P. Kumar
Manju Moorthy
Shivaram P. Singh
Deepak Suvarna
Suma M. Nataraj

Institutions

JSS Academy of Higher Education and Research (IN)

Publication Details

Journal: Molecular Medicine
Published: 2026-01-13
DOI: https://doi.org/10.1186/s10020-025-01417-w
Primary Topic: Liver Disease Diagnosis and Treatment
Type: article
Field-Weighted Citation Impact: 0.00

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article

Hepatic loss of AATF attenuates MASH by suppressing AKT–mTORC1 signaling and reprogramming lipid metabolism

Diwakar Suresh, Divya P. Kumar, Akshatha N. Srinivas, Gopalkrishna Ramaswamy et al.

Jan 13, 2026

Molecular Medicine

Liver Disease Diagnosis and Treatment

article

Hepatic loss of AATF attenuates MASH by suppressing AKT–mTORC1 signaling and reprogramming lipid metabolism

Diwakar Suresh, Divya P. Kumar, Akshatha N. Srinivas, Gopalkrishna Ramaswamy, Divya P. Kumar, Manju Moorthy, Shivaram P. Singh, Deepak Suvarna, Suma M. Nataraj

January 13, 2026article en

Abstract

Our findings reveal a previously unrecognized role of AATF as a central regulator of hepatic lipid metabolism in MASH, acting through the AKT-mTORC1 signaling pathway, and establish its inhibition as a promising therapeutic strategy for the treatment of metabolic liver disease.

Molecular MedicineVol. 32(1)

JSS Academy of Higher Education and Research (IN)

Good health and well-being

Openalex Percentile: Top 89%

Liver Disease Diagnosis and Treatment

DOI Open Access PDF OpenAlex

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