PKM2 preconditioning protects endothelial cells from pyroptosis and BBB disruption via NRF2/TRX/TXNIP signaling in neonatal hypoxic-ischemic brain injury
Our analyses provide compelling evidence that PKM2 preconditioning attenuates endothelial cell pyroptosis and BBB disruption in neonatal HIBD by causing oxidative stress resistance and activating the NRF2/TRX/TXNIP pathway. Therefore, PKM2 represents a promising pharmacological target for treating HIBD.
Authors
- GuoSheng Yu
- Li Ma (ORCID: https://orcid.org/0000-0001-7002-6626)
- Nan Yan (ORCID: https://orcid.org/0000-0001-6729-2448)
- Liying Lu
- Yani Feng
- Xingyun Wang
- Jianghu Zhu
- Xinyi Wang
- Yingying Hu
Institutions
- Wenzhou Medical University (CN)
- Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University (CN)
- Tongren Hospital (CN)
Publication Details
- Journal
- Journal of Neuroinflammation
- Published
- 2026-01-13
- DOI
- https://doi.org/10.1186/s12974-026-03694-6
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00