A non-invasive secreted protein-based gene signature for prognostic stratification and tumor microenvironment assessment in gastric cancer
We established a non-invasive 8-SPCG signature that may serve as a potential predictor for GC prognosis and TME features. SERPINE1 was identified as a promising mediator linking GC progression to CAFs interactions, supporting its further investigation as a therapeutic target.
Authors
- Qianlong Shen
- Qiuxia Liu Liu
- Ziming Wang (ORCID: https://orcid.org/0000-0002-6949-2352)
- Jianguo Zhao (ORCID: https://orcid.org/0000-0001-6587-4823)
- Xianhe Xie (ORCID: https://orcid.org/0009-0004-2254-2975)
- Haofeng Yin
Institutions
- Fujian Medical University (CN)
- Shaoxing University (CN)
- First Affiliated Hospital of Fujian Medical University (CN)
- Shaoxing People's Hospital (CN)
Publication Details
- Journal
- PeerJ
- Published
- 2026-01-13
- DOI
- https://doi.org/10.7717/peerj.20517
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00