Association and impact of inflammatory markers and cardiac structure on atrial fibrillation risk: a study integrating NHANES with real-world data

This study suggests that elevated SIRI may represent a potential biomarker and is associated with an increased risk of AF, and found that left atrial diameter may partially mediate this relationship, suggesting SIRI as a potential inflammatory biomarker for AF prediction. Although other CBC-derived markers did not show significant associations, the results underscore inflammation's role in AF pathogenesis. Further longitudinal studies are needed to validate these findings and clarify the underlying mechanisms.