Immunological and molecular insights into acinar-ductal metaplasia and atypical flat lesions as precursor lesions of pancreatic ductal adenocarcinoma
Our study highlights the unique immunological and stromal features of AFL. Moreover, reinforcing their potential as precursor lesions, ADM and AFL exhibit variable alterations in the genes that have a critical role in PDAC carcinogenesis.
Authors
- Wolfgang Goering
- Martin Schlensog
- Kai Horny (ORCID: https://orcid.org/0000-0003-4401-997X)
- Leon Boshoven
- Lena Häberle (ORCID: https://orcid.org/0000-0002-8793-568X)
- Sebastian Haensch
- Aslihan Yavas
- Irene Esposito
Institutions
- Düsseldorf University Hospital (DE)
- Heinrich Heine University Düsseldorf (DE)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2026-01-13
- DOI
- https://doi.org/10.1186/s13046-026-03643-4
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00