Age‐Related Risk Stratification in <scp>HPV</scp> ‐Positive Oropharyngeal Cancer: Implications for Treatment De‐Intensification

This study developed a risk stratification model for patients with p16-positive OPC based on the AJCC eighth edition staging and age. Patients in the extremely low-risk group may derive limited benefit from concurrent chemotherapy, suggesting that its omission could be considered in selected patients and may help guide the design of future de-escalation trials.

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Publication Details

Journal
Head & Neck
Published
2026-01-12
DOI
https://doi.org/10.1002/hed.70167
Primary Topic
Head and Neck Cancer Studies
Type
article
Field-Weighted Citation Impact
0.00
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article

Age‐Related Risk Stratification in HPV ‐Positive Oropharyngeal Cancer: Implications for Treatment De‐Intensification

Genghao Zhao, Chuanhao Zhang, Ruoyu Wang, Yingming Sun et al.
Head & Neck
Head and Neck Cancer Studies
article

Age‐Related Risk Stratification in HPV ‐Positive Oropharyngeal Cancer: Implications for Treatment De‐Intensification

Genghao Zhao, Chuanhao Zhang, Ruoyu Wang, Yingming Sun, Shanshan Liang, Yanmei Zhu, Zhe Wang, Zhichao Cheng, Bowen Hou, Xin Jiang, Ye Zhang
article en

Abstract

This study developed a risk stratification model for patients with p16-positive OPC based on the AJCC eighth edition staging and age. Patients in the extremely low-risk group may derive limited benefit from concurrent chemotherapy, suggesting that its omission could be considered in selected patients and may help guide the design of future de-escalation trials.

Head & Neck
Fujian Medical University (CN), Dalian Medical University (CN), Jilin University (CN), Chinese Academy of Medical Sciences & Peking Union Medical College (CN), National Cancer Center (US), First Hospital of Jilin University (CN), Affiliated Zhongshan Hospital of Dalian University (CN), Sanming University (CN), High Throughput Biology (United States) (US)
Good health and well-being
Openalex Percentile: Top 90%
Head and Neck Cancer Studies
DOISourceOpenAlex
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Age‐Related Risk Stratification in <scp>HPV</scp> ‐Positive Oropharyngeal Cancer: Implications for Treatment De‐Intensification — Genghao Zhao, Chuanhao Zhang, et al. · Head & Neck (2026) | TGRS Research Map | TGRS