Ecliptasaponin A alleviates inflammation and fibrosis in experimental MASH mice via targeting the NLRP3 inflammasome and YAP signaling pathway
These findings reveal novel perspectives on the natural compound Ecliptasaponin A, demonstrating its dual-targeting capability against both NLRP3 inflammasome activation and YAP signaling cascades. This discovery highlights its potential as a promising therapeutic agent for mitigating MASH.
Authors
- Wangting Li
- Kai Gao (ORCID: https://orcid.org/0000-0002-9251-8231)
- Xingru Tao
- Wei Zhang
- Yunyang Lu
- Yang Du
- Meiyou Liu
- Chao Guo
- Fuxing Jin
- Meina Zhao
- Dong Xu
- Jingwen Wang
Institutions
- Xijing Hospital (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- Chinese Medicine
- Published
- 2026-01-13
- DOI
- https://doi.org/10.1186/s13020-025-01321-9
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00