Associations between the brain glymphatic system and mitochondrial (dys)function: a systematic review

The relationship between mitochondria and the glymphatic system is complex. Further research is needed to clarify the precise mechanisms of interaction as the current literature is largely speculative. Existing evidence suggests that mitochondrial abnormalities are present in iNPH and IIH, conditions related to impaired CSF flow and impaired glymphatic function. In addition, sleep and melatonin potentially link mitochondrial activity and the glymphatic system function and thus offer potential avenues to ameliorate disorders associated with glymphatic dysfunction by enhancing mitochondrial activity.