Hospital-adapted inhaled phage therapy for ventilator-associated pneumonia caused by multidrug-resistant Klebsiella pneumoniae: a comparative pilot study
This comparative pilot study outlines a translational approach from local K. pneumoniae epidemiology to hospital-adapted phage cocktails. Although preliminary, our findings illustrate how this pragmatic approach could be evaluated into intensive care unit workflows, positioning hospital-adapted cocktails as a potential middle ground between broad-spectrum and personalized phage therapy.
Authors
- Fedor Zurabov (ORCID: https://orcid.org/0000-0001-7947-1128)
- Marina M. Gurkova (ORCID: https://orcid.org/0000-0001-6473-9566)
- Tatyana N. Kochetova
- Andrey V. Grechko (ORCID: https://orcid.org/0000-0003-3318-796X)
- Roman Gorodnichev
- Dmitry Bespiatykh (ORCID: https://orcid.org/0000-0003-0867-5988)
- Viktoria Uskevich
- Anastasiia O. Krivulia (ORCID: https://orcid.org/0009-0007-7117-1519)
- Nikolay I. Khromykh (ORCID: https://orcid.org/0009-0001-6806-3548)
- Egor Shitikov
- Oleg Goloshchapov
- Marina Petrova
- Maja Malakhova
- Maria Kornienko
- Marina Zaychikova
- Julia Bespyatykh
- Alexey Yakovlev
Institutions
- D. Mendeleyev University of Chemical Technology of Russia (RU)
- Microsemi (Canada) (CA)
- First Pavlov State Medical University of St. Petersburg (RU)
- Energostal (Ukraine) (UA)
- V.A. Negovsky Scientific Research Institute of General Reanimatology (RU)
- Federal Medical-Biological Agency (RU)
Publication Details
- Journal
- Critical Care
- Published
- 2026-01-13
- DOI
- https://doi.org/10.1186/s13054-026-05839-8
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.00