Alterations in brain metabolites in rats with experimental periodontitis: A metabolomic approach
While periodontitis has been associated with neuroinflammation and behavioral impairments, the specific metabolic changes in central nervous system structures such as the hippocampus and amygdala remain poorly understood. This study identified altered metabolite profiles in the hippocampus and amygdala of rats with ligature-induced periodontitis, involving compounds associated with neuroinflammatory pathways and behavioral dysfunctions. These findings provide novel insight into the biochemical mechanisms linking periodontal inflammation with neurological outcomes and support further investigation into periodontitis as a potential modifiable risk factor for neuropsychiatric and cognitive disorders.
Authors
- Ramona Ramalho de Souza Pereira (ORCID: https://orcid.org/0009-0006-6971-2366)
- Elizabeth Luciana Marinho Miguel (ORCID: https://orcid.org/0000-0003-4852-1430)
- Larissa Vieira Toledo (ORCID: https://orcid.org/0000-0002-1353-834X)
- Alan Rodrigues Teixeira Machado (ORCID: https://orcid.org/0000-0002-4803-4600)
- Luciano José Pereira (ORCID: https://orcid.org/0000-0001-9533-8589)
- Marco Fabrício Dias‐Peixoto (ORCID: https://orcid.org/0000-0003-3324-3634)
- Débora Ribeiro Orlando (ORCID: https://orcid.org/0000-0002-0129-0818)
- Eric Francelino Andrade
- Bruno Del Bianco Borges
- Caíque Olegário Diniz e Magalhães
Institutions
- Universidade Federal de Lavras (BR)
- Universidade do Estado de Minas Gerais (BR)
- Universidade Federal dos Vales do Jequitinhonha e Mucuri (BR)
Publication Details
- Journal
- Journal of Periodontology
- Published
- 2026-01-12
- DOI
- https://doi.org/10.1002/jper.70069
- Primary Topic
- Oral microbiology and periodontitis research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fundação de Amparo à Pesquisa do Estado de Minas Gerais