Survival and multi-omics analysis of immunotherapy-based conversion treatment for initially unresectable gastric cancer

ICIs-based conversion therapy demonstrates promising survival benefits and manageable safety profiles for patients with unresectable locally advanced or oligometastatic gastric cancer, and provides real-world evidence for a potential treatment strategy. Additionally, multi-omics findings have revealed drug resistance mechanisms and potential biomarkers of efficacy.

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Publication Details

Journal
Frontiers in Immunology
Published
2026-01-13
DOI
https://doi.org/10.3389/fimmu.2025.1753749
Primary Topic
Gastric Cancer Management and Outcomes
Type
article
Field-Weighted Citation Impact
0.00

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article

Survival and multi-omics analysis of immunotherapy-based conversion treatment for initially unresectable gastric cancer

Xiaohan Cui, Xin Dai, Qian Xu, Wen Zhao et al.
Frontiers in Immunology
Gastric Cancer Management and Outcomes
article

Survival and multi-omics analysis of immunotherapy-based conversion treatment for initially unresectable gastric cancer

Xiaohan Cui, Xin Dai, Qian Xu, Wen Zhao, Lian Liu, Song Li, Zhaodi Nan, Duanbo Shi, Di Zhang, Zimin Liu, Shulun Nie, Shuang Wang, Wenbin Yu, Meng Wei, Xinyu Song
article en

Abstract

ICIs-based conversion therapy demonstrates promising survival benefits and manageable safety profiles for patients with unresectable locally advanced or oligometastatic gastric cancer, and provides real-world evidence for a potential treatment strategy. Additionally, multi-omics findings have revealed drug resistance mechanisms and potential biomarkers of efficacy.

Frontiers in ImmunologyVol. 16
Qingdao University (CN), Shandong University of Traditional Chinese Medicine (CN), Jining Traditional Chinese Medicine Hospital (CN), Shandong Provincial Hospital (CN), Affiliated Hospital of Qingdao University (CN), Qilu Hospital of Shandong University (CN)
National Natural Science Foundation of China
Good health and well-being
Openalex Percentile: Top 90%
Gastric Cancer Management and Outcomes
DOIOpen Access PDFOpenAlex
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Survival and multi-omics analysis of immunotherapy-based conversion treatment for initially unresectable gastric cancer — Xiaohan Cui, Xin Dai, et al. · Frontiers in Immunology (2026) | TGRS Research Map | TGRS