Pharmacokinetics and safety of <scp>HR17031</scp> , a fixed‐ratio of <scp>INS068</scp> /Noiiglutide combination, in Chinese patients with hepatic impairment
HR17031 demonstrated PK profiles of INS068 and Noiiglutide comparable between subjects with mild or moderate hepatic impairment and those with normal hepatic function, with modest reductions in moderate impairment. The treatment was well tolerated with a favourable safety profile, and no significant differences in C-peptide concentrations were observed across groups.
Authors
- Lei Diao (ORCID: https://orcid.org/0000-0002-4103-7294)
- Jiajia Mai
- Yan Zhang (ORCID: https://orcid.org/0000-0002-2947-1629)
- Hongda Lin
- Y. X. Ding
- Xuehu Gao
- Di Wang
Institutions
- Jilin University (CN)
- First Hospital of Jilin University (CN)
- Jiangsu Hengrui Medicine (China) (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Diabetes Obesity and Metabolism
- Published
- 2026-01-12
- DOI
- https://doi.org/10.1111/dom.70450
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00