Effects of ascorbic acid and cholecalciferol on growth factor release, cytokines, and biomechanical properties of platelet rich fibrin: in vitro study
The addition of ascorbic acid and cholecalciferol to PRF enhanced its mechanical properties and exhibited favorable biological effects on growth factors and inflammatory processes. These findings suggest that vitamin-enriched PRF could be a promising approach for optimizing periodontal regeneration.
Authors
- Bahar Alkaya (ORCID: https://orcid.org/0000-0003-2064-5896)
- Onur Uçak Türer (ORCID: https://orcid.org/0000-0002-4252-174X)
- Mehmet Bertan Yılmaz (ORCID: https://orcid.org/0000-0001-5558-3299)
- Mustafa Özcan (ORCID: https://orcid.org/0000-0002-5562-553X)
- Bedii Ender Topcu
- M. Cenk Haytac
Institutions
- Cukurova University (TR)
Publication Details
- Journal
- BMC Oral Health
- Published
- 2026-01-13
- DOI
- https://doi.org/10.1186/s12903-025-07620-9
- Primary Topic
- Periodontal Regeneration and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00