Blood-brain barrier integrity and prevalence of intrathecal T helper 17.1 cells in Huntington´s disease
We found no evidence of increased BBB/BCB leakage of albumin in HDGECs compared to controls. Neither did we find signs of pericyte involvement as measured by PDGFR-β in HDGECs. These results suggest that overt BBB/BCB disruption may be limited in HDGECs. Future longitudinal studies should employ more sensitive methods like dynamic contrast-enhanced magnetic resonance imaging to evaluate region specific microleaks.
Authors
- Christian Sandøe Musaeus (ORCID: https://orcid.org/0000-0002-6442-2910)
- Patrick Ejlerskov (ORCID: https://orcid.org/0000-0002-2514-3185)
- Niels H. Skotte (ORCID: https://orcid.org/0000-0001-7027-7193)
- Marina Rode von Essen (ORCID: https://orcid.org/0000-0001-9367-5020)
- Jørgen E. Nielsen (ORCID: https://orcid.org/0000-0003-0453-5582)
- Finn Sellebjerg
- Lena E. Hjermind
- Anja Hviid Simonsen
- Esben Budtz-Jørgensen
- Birna Ásbjörnsdóttir
- Marie N. N. Hellem
- Tua Vinther-Jensen
- Filippa Liliendahl Qvist
Institutions
- University of Copenhagen (DK)
- Copenhagen University Hospital (DK)
- Danish Multiple Sclerosis Center (DK)
Publication Details
- Journal
- PLoS ONE
- Published
- 2026-01-12
- DOI
- https://doi.org/10.1371/journal.pone.0340683
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Bristol-Myers Squibb
- Sanofi
- Biogen
- Lundbeckfonden
- Eisai
- Novo Nordisk
- Novo Nordisk Fonden
- H. Lundbeck A/S