Cardiopathogenic T Cells Govern Progression and Functional Remodeling in Inflammatory Cardiomyopathy and Chronic Myocarditis
Echocardiographic imaging mirrors the immunopathological processes underlying the progression from acute myocarditis to inflammatory cardiomyopathy. T cell-mediated myocardial inflammation and edematous swelling in subepicardial regions at disease onset is followed by smoldering low-level myocardial inflammation or increasing cardiomyocyte loss and fibrotic remodeling. The resulting decline of cardiac function in the progressive disease is reflected and best predicted by impaired echocardiographic strain.
Authors
- Anna Joachimbauer
- Kira Frischmann
- Burkhard Ludewig (ORCID: https://orcid.org/0000-0002-7685-573X)
- H Rickli
- Isabella Hanka
- Felix Christoph Tanner (ORCID: https://orcid.org/0000-0002-4315-2667)
- Nadine Cadosch (ORCID: https://orcid.org/0009-0007-0825-1014)
- Micha T. Maeder
- Emily Payne
- Cristina Gil-Cruz
- Frank Ruschitzka
- Christian Perez-Shibayama
- Dörthe Schmidt
Institutions
- University of Zurich (CH)
- University of St.Gallen (CH)
- Kantonsspital St. Gallen (CH)
- University Hospital of Zurich (CH)
Publication Details
- Journal
- JACC Basic to Translational Science
- Published
- 2026-01-12
- DOI
- https://doi.org/10.1016/j.jacbts.2025.101458
- Primary Topic
- Viral Infections and Immunology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00