Postoperative reduction in thrombin generation induced by elevated levels of tissue factor pathway inhibitor in cardiac surgery: a prospective observational study
In patients undergoing cardiac surgery using CPB, the increase in plasma TFPI concentration at the end of surgery causes a reduction in TG and impairment of whole blood coagulation via a mechanism that includes inhibition of factor Xa activity.
Authors
- Akiko Kitajo
- Aya Takemoto
- Tokujiro Uchida (ORCID: https://orcid.org/0000-0002-9474-0020)
- Yudai Yamamoto (ORCID: https://orcid.org/0000-0003-3005-6243)
- Nobuyo Umehara
- Tomoyuki Fujita
Institutions
- Tokyo Medical and Dental University (JP)
Publication Details
- Journal
- Journal of Anesthesia
- Published
- 2026-01-13
- DOI
- https://doi.org/10.1007/s00540-026-03657-4
- Citations
- 2
- Primary Topic
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Type
- article
- Field-Weighted Citation Impact
- 80.17
Funders
- Japan Society for the Promotion of Science