The depletion of serine beta‐lactamase‐like protein (LACTB) ameliorates metabolic dysfunction–associated steatotic liver disease by reducing ubiquitin‐mediated degradation of carnitine palmitoyltransferase 2
Our findings indicate that LACTB is a novel regulatory factor in MASLD by influencing the ubiquitin-mediated degradation of CPT2 to participate in disease progression. These findings may provide a novel potential therapeutic strategy for MASLD.
Authors
- Chengru Yang (ORCID: https://orcid.org/0009-0003-4320-0723)
- Xiangyu zhong
- Xinlei Zou
- Yapeng Li (ORCID: https://orcid.org/0000-0002-9571-0587)
- Gao Jianjun
- Shaowu Bi
- Canghai Guan
- Xin Liu
- Nan Wang
- Wujiang Shi
Institutions
- Harbin Engineering University (CN)
- Harbin Medical University (CN)
Publication Details
- Journal
- Diabetes Obesity and Metabolism
- Published
- 2026-01-13
- DOI
- https://doi.org/10.1111/dom.70483
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00