Ketamine Improves Anhedonic Phenotypes Across Species: Translational Evidence From the Probabilistic Reward Task
Results highlight a shared behavioral mechanism through which ketamine alleviates anhedonic behaviors and offers important implications for the treatment of people with anhedonia in TRD and related psychopathologies.
Authors
- Daniela Radl
- Brian D. Kangas (ORCID: https://orcid.org/0000-0002-4597-9801)
- Shiba M. Esfand (ORCID: https://orcid.org/0009-0009-1536-4062)
- Samantha R. Linton (ORCID: https://orcid.org/0000-0001-7512-1585)
- Ty Lees (ORCID: https://orcid.org/0000-0002-7321-2704)
- Amaya R. Jenkins (ORCID: https://orcid.org/0000-0002-1919-9940)
- Thomas Kornecook
- Mohan Li
- Mario Bogdanov
- Jason N. Scott
- Paula Bolton
- Robert C. Meisner
- Courtney Miller
- Sarah E. Woronko
- Diego A. Pizzagalli
- Brian W. Boyle
- Shuang Li
Institutions
- Harvard University (US)
- University of California, Irvine (US)
- McLean Hospital (US)
- Massachusetts General Hospital (US)
- Neurocrine Biosciences (United States) (US)
Publication Details
- Journal
- Biological Psychiatry Global Open Science
- Published
- 2026-01-13
- DOI
- https://doi.org/10.1016/j.bpsgos.2026.100688
- Primary Topic
- Treatment of Major Depression
- Type
- article
- Field-Weighted Citation Impact
- 0.00