Spatial and single-cell multi-omics reveal pro-angiogenic THY1⁺ fibroblast subtypes predicting prognosis in prostate cancer
THY1⁺ CAFs represent a proangiogenic subset that drives PCa progression via the CXCL6/CXCR2 axis and THY1-mediated VEGFA expression. These findings highlight stromal THY1 and the CXCL6/CXCR2 pathway as potential therapeutic targets.
Authors
- W. Zhang
- Yi Huang
- Leilei Du
- Guohai Shi
- Chunping Xiang
- Yu Wang
- Wenfeng Wang
- Jianhua Wang
Institutions
- Shanghai Jiao Tong University (CN)
- Fudan University Shanghai Cancer Center (CN)
- Shanghai Ninth People's Hospital (CN)
Publication Details
- Journal
- Translational Oncology
- Published
- 2026-01-12
- DOI
- https://doi.org/10.1016/j.tranon.2026.102664
- Primary Topic
- Prostate Cancer Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00