The safety and efficacy of GD2-targeted CAR-T cells in patients with neuroblastoma: a systematic review and meta-analysis

CAR-T-cell therapy targeting the GD2 antigen is promising for treating NB. However, its efficacy is moderate, and treatment can lead to hematologic toxicities such as anemia, neutropenia, and thrombocytopenia, which require careful monitoring.

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Publication Details

Journal
European journal of medical research
Published
2026-01-13
DOI
https://doi.org/10.1186/s40001-025-03764-0
Primary Topic
CAR-T cell therapy research
Type
article
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article

The safety and efficacy of GD2-targeted CAR-T cells in patients with neuroblastoma: a systematic review and meta-analysis

Behrouz Robat-Jazi, Mahsa Ahmadpour, Negar Nejati, Sajjad Ahmadpour et al.
European journal of medical research
CAR-T cell therapy research
article

The safety and efficacy of GD2-targeted CAR-T cells in patients with neuroblastoma: a systematic review and meta-analysis

Behrouz Robat-Jazi, Mahsa Ahmadpour, Negar Nejati, Sajjad Ahmadpour, Ali Zand, Mohammad Amin Habibi, Mohsen Dashti, Parsa Lorestan, Farzad Maleki, Zahra Karimizadeh, Alireza Khodadadiyan
article en

Abstract

CAR-T-cell therapy targeting the GD2 antigen is promising for treating NB. However, its efficacy is moderate, and treatment can lead to hematologic toxicities such as anemia, neutropenia, and thrombocytopenia, which require careful monitoring.

European journal of medical researchVol. 31(1)
Tabriz University of Medical Sciences (IR), Shiraz University of Medical Sciences (IR), Islamic Azad University Medical Branch of Tehran (IR), Urmia University (IR), Kermanshah University of Medical Sciences (IR), Shariati Hospital (IR), Stem Cell Technology Research Center (IR), Faghihi Hospital (IR), Tehran University of Medical Sciences (IR)
Good health and well-being
Openalex Percentile: Top 89%
CAR-T cell therapy research
DOIOpen Access PDFOpenAlex
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The safety and efficacy of GD2-targeted CAR-T cells in patients with neuroblastoma: a systematic review and meta-analysis — Behrouz Robat-Jazi, Mahsa Ahmadpour, et al. · European journal of medical research (2026) | TGRS Research Map | TGRS