Longitudinal trajectories of cognitive decline and temporal lobe atrophy based on baseline gonadotropins and testosterone
The results indicate that in individuals across the AD spectrum, elevated gonadotropin levels may exert deleterious, domain-specific effects on cognitive decline or temporal lobe atrophy. Women with lower TT levels may experience faster cognitive progression. Although future studies incorporating additional longitudinal hormone measurements and cognitive trajectories are warranted, our results underscore the importance of gonadotropins and testosterone in AD progression.
Authors
- wenyi li
- Tianlin Jiang (ORCID: https://orcid.org/0000-0002-7844-3624)
- Shirui Jiang (ORCID: https://orcid.org/0000-0002-3324-7785)
- Qiwei Ren
- Huiying Zhang
- Min Zhao
- Jun Xu
- Shiyi Yang
- Linlin Wang
- Jiwei Jiang
- Junya Zhou
Institutions
- Capital Medical University (CN)
- Beijing Tian Tan Hospital (CN)
- National Clinical Research Center for Digestive Diseases (CN)
- Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital (CN)
- Beijing Friendship Hospital (CN)
Publication Details
- Journal
- Frontiers in Neuroscience
- Published
- 2026-01-13
- DOI
- https://doi.org/10.3389/fnins.2025.1696274
- Primary Topic
- Menopause: Health Impacts and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00