Targeting and dissociating HIF2α from the molecular chaperone Hsp70 triggers apoptosis in kidney cancer
The distinctive inhibitory mechanism of the HIF2α inhibitor identified here, Compound-c2, sets it apart from previous HIF2α antagonists. This positions Compound-c2 as a promising alternative with potential applications in addressing drug resistance, providing a unique approach to inhibit HIF2α-related processes.
Authors
- Michael F. Basin (ORCID: https://orcid.org/0000-0002-2905-0824)
- Gennady Bratslavsky (ORCID: https://orcid.org/0000-0002-2712-4375)
- Jennifer Heritz (ORCID: https://orcid.org/0000-0001-7259-8046)
- Sarah J. Backe (ORCID: https://orcid.org/0000-0001-9275-267X)
- Britannia M. Smith
- Angela Pacherille
- Rebecca Sager
- Michael Daneshvar (ORCID: https://orcid.org/0000-0002-0670-1110)
- Mehdi Mollapour (ORCID: https://orcid.org/0000-0002-2144-1361)
- Dimitra Bourboulia (ORCID: https://orcid.org/0000-0002-8567-2775)
- John D. Chisholm (ORCID: https://orcid.org/0000-0001-9518-2393)
- Mark R. Woodford (ORCID: https://orcid.org/0000-0002-6737-2832)
- Dawn E. Post
- Sara J Cayaban
Institutions
- SUNY Upstate Medical University (US)
- University of California, Irvine (US)
- Syracuse University (US)
Publication Details
- Journal
- Communications Medicine
- Published
- 2026-01-12
- DOI
- https://doi.org/10.1038/s43856-025-01356-x
- Citations
- 1
- Primary Topic
- Heat shock proteins research
- Type
- article
- Field-Weighted Citation Impact
- 22.24
Funders
- State University of New York
- National Institutes of Health
- State University of New York Upstate Medical University
- National Institute of General Medical Sciences