Impact of Metformin and Diabetes on Tumor Response to Total Neoadjuvant Therapy in Advanced Rectal Cancer: A Multicenter Retrospective Cohort Study
Diabetes and metformin use did not significantly affect tumor response rates in the overall cohort of patients with advanced rectal cancer treated with TNT. However, among diabetic patients, metformin use was associated with improved response to TNT. Given the retrospective design and limited sample size, large-scale prospective studies are required to validate these findings.
Authors
- Sudarsha Selva‐Nayagam
- Michael Penniment (ORCID: https://orcid.org/0000-0001-8010-0789)
- Mahima Raju
- Tracy Fitzsimmons (ORCID: https://orcid.org/0000-0002-1029-8352)
- Tarik Sammour
- Ishraq Murshed
- Timothy J. Price
- Sergei Bedrikovetski
Institutions
- Royal Adelaide Hospital (AU)
- Queen Elizabeth Hospital (AU)
- The University of Adelaide (AU)
Publication Details
- Journal
- Asia-Pacific Journal of Clinical Oncology
- Published
- 2026-01-12
- DOI
- https://doi.org/10.1111/ajco.70076
- Primary Topic
- Metabolism, Diabetes, and Cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Cancer Council South Australia