Deciphering reprogramming efficiency in human induced pluripotent stem cells: insights from the generation of 150 cell lines
We found that the most relevant factor influencing reprogramming efficiency is the developmental status of the starting cells. While other parameters may exert minor effects, inherent donor-specific biological characteristics appear to play the strongest role in determining reprogramming outcomes.
Authors
- Bernd Kuebler (ORCID: https://orcid.org/0000-0002-4472-871X)
- Angel Alcaide Raya
- Begoña Arán (ORCID: https://orcid.org/0000-0002-5011-7755)
- Silvia Selvitella
- Anna Veiga
Institutions
- Institució Catalana de Recerca i Estudis Avançats (ES)
- Institut d'Investigació Biomédica de Bellvitge (ES)
- Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (ES)
- Ajuntament de L’Hospitalet (ES)
- Department of Physiological Sciences (RU)
- Center of Regenerative Medicine in Barcelona (ES)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-13
- DOI
- https://doi.org/10.3389/fimmu.2025.1719056
- Primary Topic
- Pluripotent Stem Cells Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Centres de Recerca de Catalunya
- European Commission
- Generalitat de Catalunya
- Agència de Gestió d'Ajuts Universitaris i de Recerca
- Instituto de Salud Carlos III