Species-specific iNOS expression distinguishes epithelial and myeloid IFNγ responses in tuberculosis
IFNγ signaling is uncoupled from iNOS induction in primate myeloid cells and epithelial compartments represent dominant sources of iNOS in human tuberculosis. These findings, challenge murine macrophage-centric paradigms and IFNγ-based correlates used in TB vaccine development and central to pathophysiology of tuberculosis and other pneumonias.
Authors
- Ralf Ewert
- Bryan David Bryson
- Bianca E. Schneider (ORCID: https://orcid.org/0000-0001-5815-5214)
- Anca Dorhoi (ORCID: https://orcid.org/0000-0003-1739-749X)
- Stefan Simm
- Frank A. W. Verreck (ORCID: https://orcid.org/0000-0002-4441-5000)
- B. Stubbe
- Fabian Stei
- Jonathan Pioch
- Bjoern Corleis
- Erin F McCaffrey
- Bjoern Zessin
Institutions
- Friedrich-Loeffler-Institut (DE)
- Coburg University of Applied Sciences (DE)
- Universitätsmedizin Greifswald (DE)
- Ragon Institute of MGH, MIT and Harvard (US)
- Biomedical Primate Research Centre (NL)
- Bioanalytica (Switzerland) (CH)
- Research Center Borstel - Leibniz Lung Center (DE)
- National Institute of Allergy and Infectious Diseases (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-01-12
- DOI
- https://doi.org/10.64898/2026.01.11.697682
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00