Diet intervention altered DNA methylation of potassium voltage-gated channel subfamily Q member 1 in metabolic dysfunction-associated steatohepatitis
The study reinforced the role of DNA methylation in regulating gene expression of KCNQ1 in response to LFD intervention and highlighted that the DNA methylation of KCNQ1 in MASH adipose tissue could be tissue-specific. All these results contribute to elucidating the molecular mechanisms underlying the activities of DNA methylation in MASH.
Authors
- Baocheng Liu (ORCID: https://orcid.org/0000-0002-8680-8400)
- Guang Ji (ORCID: https://orcid.org/0000-0002-6349-5114)
- Xinying Xiong
- Hualing Song (ORCID: https://orcid.org/0009-0007-4342-4339)
- Na Wu
- Xinyu Shi
- Shengfu You
- Lei Zhang
- Shuang Wei
- Wenjun Zhou
Institutions
- Shanghai University of Traditional Chinese Medicine (CN)
- Longhua Hospital Shanghai University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Clinical Epigenetics
- Published
- 2026-01-13
- DOI
- https://doi.org/10.1186/s13148-025-01950-9
- Citations
- 1
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 30.93