Hybrid closed‐loop insulin delivery improves glycaemic control compared with sensor‐augmented pump therapy: A meta‐analysis of ‘free‐living’ randomised trials in type 1 diabetes
Our findings support HCLS as a superior modality to SAP therapy in improving glycaemic control, particularly in paediatric populations. HCLS effectively reduces hyperglycaemia and increases TIR, with modest effects on hypoglycaemia. The clinical implications are significant, highlighting the advantages of HCLS in optimising glucose regulation and mitigating glycaemic variability. This technology offers improved glycaemic control and enhanced quality of life for people living with type 1 diabetes.
Authors
- Thomas J. Wilkinson (ORCID: https://orcid.org/0000-0002-7855-7752)
- Patrick Highton (ORCID: https://orcid.org/0000-0002-0410-5788)
- Amardeep Sidki
- Lauren L. O'Mahoney
Institutions
- University of Leicester (GB)
- Leicester General Hospital (GB)
- University Hospitals of Leicester NHS Trust (GB)
- NIHR Leicester Biomedical Research Centre (GB)
Publication Details
- Journal
- Diabetic Medicine
- Published
- 2026-01-13
- DOI
- https://doi.org/10.1111/dme.70210
- Primary Topic
- Diabetes Management and Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute for Health and Care Research
- Department of Health and Social Care
- NIHR Leicester Biomedical Research Centre