Activation of NF-κB signaling pathway in GSDME-low esophageal squamous cell carcinoma cells enhances radioresistance
GSDME functions as a tumor suppressor by enhancing radiosensitivity and inhibiting proliferation and migration in ESCC, through the suppression of the NF-κB signaling pathway. These findings nominate GSDME as a promising biomarker and the NF-κB signaling pathway as a therapeutic target for overcoming radioresistance in ESCC.
Authors
- Renya Zeng (ORCID: https://orcid.org/0000-0003-0667-8165)
- Lingli Lei
- Bing Wang
- Minghui Chang
- Zhe Yang
- Yi Zhao
Institutions
- Qingdao University (CN)
- Shandong University (CN)
- Shandong Provincial Hospital (CN)
- Affiliated Hospital of Qingdao University (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2026-01-13
- DOI
- https://doi.org/10.1186/s12967-025-07635-4
- Primary Topic
- Glutathione Transferases and Polymorphisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00