Novel Substituted Pyrazolo-Pyrimidine Compounds as PIKfyve Inhibitors for Treating Neurological Diseases

Provided herein are novel substituted pyrazolo-pyrimidine compounds as PIKfyve inhibitors, pharmaceutical compositions, use of such compounds in treating neurological diseases, and processes for preparing such compounds.

Authors

Anika R. Sabnis (ORCID: https://orcid.org/0009-0008-9940-6583)
Ram W. Sabnis

Institutions

Mayo Clinic (US)

Publication Details

Journal: ACS Medicinal Chemistry Letters
Published: 2026-01-12
DOI: https://doi.org/10.1021/acsmedchemlett.6c00012
Primary Topic: Biochemical and Molecular Research
Type: article
Field-Weighted Citation Impact: 0.00

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article

Novel Substituted Pyrazolo-Pyrimidine Compounds as PIKfyve Inhibitors for Treating Neurological Diseases

Anika R. Sabnis, Ram W. Sabnis

Jan 12, 2026

ACS Medicinal Chemistry Letters

Biochemical and Molecular Research

article

Novel Substituted Pyrazolo-Pyrimidine Compounds as PIKfyve Inhibitors for Treating Neurological Diseases

Anika R. Sabnis, Ram W. Sabnis

January 12, 2026article en

Abstract

ACS Medicinal Chemistry LettersVol. 17(2)

Mayo Clinic (US)

Openalex Percentile: Top 90%

Biochemical and Molecular Research

DOI Open Access PDF OpenAlex

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Novel Substituted Pyrazolo-Pyrimidine Compounds as PIKfyve Inhibitors for Treating Neurological Diseases — Anika R. Sabnis, Ram W. Sabnis · ACS Medicinal Chemistry Letters (2026) | TGRS Research Map | TGRS