<scp> <i>PNPLA3</i> </scp> Genotype and Clinical Factors Impact Hepatocellular Carcinoma Risk: Findings From a Prospective Cohort Study
The frequency of rs738409-G alleles was associated with a dose-dependent increase in HCC risk and was independent of other clinical risk factors. Among participants who were male, overweight, and those with diabetes, the risk of HCC was further elevated among those with rs738409-G alleles. These data may be helpful for the development of future risk stratification strategies.
Authors
- Renwei Wang
- Woon‐Puay Koh (ORCID: https://orcid.org/0000-0002-5674-6341)
- Yen Thi‐Hai Pham (ORCID: https://orcid.org/0009-0001-3235-2110)
- Jaideep Behari (ORCID: https://orcid.org/0000-0001-8077-5137)
- Hung Nguyen Luu (ORCID: https://orcid.org/0000-0002-2172-1849)
- Huang Dj
- Jianmin Yuan
- Chiea Chuen Khor
- Zhongjie Zhang
- Rajkumar Dorajoo
Institutions
- Agency for Science, Technology and Research (SG)
- Houston Methodist (US)
- National University of Singapore (SG)
- University of Pittsburgh (US)
- Singapore Institute for Clinical Sciences (SG)
- UPMC Hillman Cancer Center (US)
- University of Pittsburgh Medical Center (US)
- National University Health System (SG)
- Genome Institute of Singapore (SG)
Publication Details
- Journal
- Alimentary Pharmacology & Therapeutics
- Published
- 2026-01-12
- DOI
- https://doi.org/10.1111/apt.70532
- Citations
- 1
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 31.52