Umbilical cord blood natural killer cells for adoptive immunotherapy: identifying optimal starting material and processing parameters
In conclusion, early isolation and cryopreservation of CD3<sup>-</sup> CBMCs from caesarean section CBUs offer an optimal starting material for use in UCB-derived NK cell immunotherapies, providing superior <i>ex vivo</i> performance and enabling batch testing to selectively expand cells from CBUs with the greatest potential.
Authors
- M. G. Kennedy
- R. Danby
- L. Wynn
- D. Hernandez
- W. Patterson
- C. Stock da Cunha
- M. O’Dwyer
- S. T. Cox
Institutions
- Ollscoil na Gaillimhe – University of Galway (IE)
- Anthony Nolan (GB)
- Churchill Hospital (GB)
- CRUK Lung Cancer Centre of Excellence (GB)
- Orbsen Therapeutics (Ireland) (IE)
- University College London (GB)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-13
- DOI
- https://doi.org/10.3389/fimmu.2025.1734453
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Anthony Nolan