Prognostic Impact of RTK–RAS Alterations in FOLFOX-Treated Early-Onset Colorectal Cancer Revealed by Artificial Intelligence-Driven Precision Oncology
RTK-RAS pathway alterations demonstrate strong age-, ancestry-, and treatment-specific prognostic effects and may serve as precision biomarkers of differential chemotherapy response. AI-enabled analytics substantially accelerated integrative biomarker discovery, supporting their utility for advancing precision oncology in EOCRC.
Authors
- Sophia Manjarrez
- Francisco G. Carranza
- Enrique Velazquez-Villarreal
- Fernando C. Diaz
- Brigette Waldrup
Institutions
- University of North Carolina at Chapel Hill (US)
- City of Hope (US)
- Beckman Research Institute
- UNC Lineberger Comprehensive Cancer Center
Publication Details
- Journal
- Cancers
- Published
- 2026-01-13
- DOI
- https://doi.org/10.3390/cancers18020239
- Citations
- 2
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 49.63