Integrating microbial genomics and neurotranscriptomics to understand the impact of probiotic strains on neurological health

This multi-omics study demonstrates mechanistic evidence that probiotics exert complementary neuromodulatory effects: <i>L. rhamnosus</i> GG primarily enhances GABAergic and SCFA-mediated synaptic pathways, whereas <i>B. longum</i> 1714 regulates the tryptophan-serotonin-immune axis. Together, these findings support the therapeutic potential of precision probiotics for neurological health and establish a systems-level framework for probing host-microbe interactions.