Intra-tumoral NK cells and their association with patient outcomes: a novel prognostic model incorporating NK cells and clinicopathologic features in gastric cancer
Gastric cancer with high NK cell infiltration is associated with increased immune activity and lower stromal cell infiltration, potentially impacting patient prognosis. Combining clinicopathological factors with NK cell score provides a powerful tool for prognostication of gastric cancer patients.
Authors
- Kizuki Yuza (ORCID: https://orcid.org/0000-0002-2419-4423)
- Kazuaki Takabe (ORCID: https://orcid.org/0000-0002-6435-4241)
- Yuko Tamura
- TAKASHI KOSAKA
- Rongrong Wu
- Masanori Oshi
- Colin J. Rog
- Li Yan
- Itaru Endo
- Takashi Ishikawa
- Hirotoshi Akiyama
Institutions
- Roswell Park Comprehensive Cancer Center (US)
- Fukushima Medical University (JP)
- Tokyo Medical University (JP)
- Niigata University Medical and Dental Hospital (JP)
- Jacobs Institute (US)
- University at Buffalo, State University of New York (US)
- Niigata University (JP)
- Yokohama City University (JP)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-13
- DOI
- https://doi.org/10.3389/fimmu.2025.1760280
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Defense
- Roswell Park Cancer Institute
- National Institutes of Health
- Japan Society for the Promotion of Science
- National Cancer Institute