Heart rate variability reflects endoscopic activity and systemic inflammation in patients with Crohn’s disease

The parasympathetic activity was reduced in active CD patients. Furthermore, the significant correlations between HRV parameters and inflammatory biomarkers underscore that HRV not only reflects endoscopic activity but also mirrors the systemic inflammatory burden in CD. Thus, HRV can potentially be developed into a simple, non-invasive tool for comprehensively assessing disease activity and inflammation in CD.