Insulin Receptor Family Autoantibodies in Patients with Type B Insulin Resistance
This study validates an InsR-aAb assay in the largest TBIR cohort to date and identifies a novel association between IRRR-aAb and bicarbonate excretion. While InsR-aAb were detected in other IR disorders, pathogenic effects were specific to TBIR.
Authors
- Thilo Samson Chillon (ORCID: https://orcid.org/0000-0001-7706-7906)
- Rebecca Brown (ORCID: https://orcid.org/0000-0001-5110-2750)
- Lutz Schomburg (ORCID: https://orcid.org/0000-0001-9445-1555)
- Marissa Lightbourne (ORCID: https://orcid.org/0000-0001-5498-0452)
- Brent S. Abel (ORCID: https://orcid.org/0000-0002-3598-0542)
- Jennifer Lee (ORCID: https://orcid.org/0000-0001-7031-9891)
- Waldemar B. Minich
Institutions
- Odense University Hospital (DK)
- National Institute of Diabetes and Digestive and Kidney Diseases (US)
- Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- The Journal of Clinical Endocrinology & Metabolism
- Published
- 2026-01-06
- DOI
- https://doi.org/10.1210/clinem/dgaf692
- Primary Topic
- Diabetes and associated disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00