Inhibitory effect of blestriarene C on triple-negative breast cancer: Inducing ferroptosis and mitophagy via SESN2/AKT/FOXO4 axis
BC emerges as a promising therapeutic agent for TNBC by targeting SESN2 and MAP1LC3B, modulating associated signaling pathways, and inducing ferroptosis and mitophagy. These findings provide the basis for further investigation of BC's potential as a targeted therapy for TNBC.
Authors
- Zhaokai Zhou (ORCID: https://orcid.org/0000-0001-6628-3750)
- Yajie Lu
- Qian Bi
- Pingting Chen (ORCID: https://orcid.org/0000-0001-6211-786X)
- Mingyu Han
- Weiwei Pan
- Cheng Peng
- Heng Zhang
- Fu Peng
- Junsha An
Institutions
- Central South University (CN)
- Sun Yat-sen University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Sichuan University (CN)
- Peking Union Medical College Hospital (CN)
- Jiaxing University (CN)
- Sun Yat-sen University Cancer Center (CN)
- Second Xiangya Hospital of Central South University (CN)
- Chengdu University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Chinese Medical Journal
- Published
- 2026-01-13
- DOI
- https://doi.org/10.1097/cm9.0000000000003960
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00