Dynamic effects of sleep deprivation on emotional behavior, circadian rhythm genes, and inflammatory infiltration in the medial prefrontal cortex

SD for 7-day or 14-day may impair emotional behaviors by disrupting the RNA expression of clock genes and the Sirt6/Hmgb1 inflammatory axis, while sleep recovery for 14-day or 21-day can partially reverse this impairment.

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Publication Details

Journal
Frontiers in Behavioral Neuroscience
Published
2026-01-13
DOI
https://doi.org/10.3389/fnbeh.2025.1742898
Primary Topic
Sleep and Wakefulness Research
Type
article
Field-Weighted Citation Impact
0.00
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article

Dynamic effects of sleep deprivation on emotional behavior, circadian rhythm genes, and inflammatory infiltration in the medial prefrontal cortex

Xue Geng, Haifeng Zhang, Shaoqiong Yi, Yong Fu et al.
Frontiers in Behavioral Neuroscience
Sleep and Wakefulness Research
article

Dynamic effects of sleep deprivation on emotional behavior, circadian rhythm genes, and inflammatory infiltration in the medial prefrontal cortex

Xue Geng, Haifeng Zhang, Shaoqiong Yi, Yong Fu, Dandan Cao
article en

Abstract

SD for 7-day or 14-day may impair emotional behaviors by disrupting the RNA expression of clock genes and the Sirt6/Hmgb1 inflammatory axis, while sleep recovery for 14-day or 21-day can partially reverse this impairment.

Frontiers in Behavioral NeuroscienceVol. 19
Jiangxi University of Traditional Chinese Medicine (CN), Guangzhou University of Chinese Medicine (CN), Guangzhou Building Materials Institute (CN), Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine (CN), Guangzhou Medical University (CN)
Openalex Percentile: Top 90%
Sleep and Wakefulness Research
DOIOpen Access PDFOpenAlex
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