Immune synapse molecules knockout in induced pluripotent stem cells enables broad NK cell resistance in T cell progeny

Our findings establish a potentially versatile platform for generating universal, NK-resistant iT cells and advance the translational potential of iPSC-based immunotherapies.

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Publication Details

Journal
Regenerative Therapy
Published
2026-01-13
DOI
https://doi.org/10.1016/j.reth.2026.101060
Primary Topic
Immune Cell Function and Interaction
Type
article
Field-Weighted Citation Impact
0.00
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article

Immune synapse molecules knockout in induced pluripotent stem cells enables broad NK cell resistance in T cell progeny

Keisuke Sumide, Tomoko Ishii, Akihiro Ishikawa, Keitaro Kanie et al.
Regenerative Therapy
Immune Cell Function and Interaction
article

Immune synapse molecules knockout in induced pluripotent stem cells enables broad NK cell resistance in T cell progeny

Keisuke Sumide, Tomoko Ishii, Akihiro Ishikawa, Keitaro Kanie, Bo Wang, Munehiro Yoshida, Shin Kaneko, Jing Zhang
article en

Abstract

Our findings establish a potentially versatile platform for generating universal, NK-resistant iT cells and advance the translational potential of iPSC-based immunotherapies.

Regenerative TherapyVol. 31
University of Tsukuba (JP), Kyoto University (JP)
Zero hunger
Openalex Percentile: Top 89%
Immune Cell Function and Interaction
DOIOpen Access PDFOpenAlex
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