Comparative risk of systemic autoimmune diseases in juvenile idiopathic arthritis treated with TNF-α or IL-6 inhibitors: a real-world cohort study
Among pediatric patients with JIA, TNF inhibitor therapy was associated with a substantially lower risk of developing systemic autoimmune diseases compared with IL-6 inhibitor therapy. These findings may inform biologic selection and long-term safety considerations in pediatric rheumatologic practice.
Authors
- Yung-Heng Lee
- Ping‐Chang Lin (ORCID: https://orcid.org/0000-0003-0918-4072)
- Li‐Teh Liu (ORCID: https://orcid.org/0000-0002-7993-7263)
- James Cheng-Chung Wei
- Yu-Hsun Wang
- Jih-Jin Tsai
Institutions
- Chung Hwa University of Medical Technology (TW)
- Ministry of Health and Welfare (KR)
- National Sun Yat-sen University (TW)
- Minghsin University of Science and Technology (TW)
- Asia University (TW)
- Kaohsiung Medical University (TW)
- China Medical University (TW)
- Chung Shan Medical University Hospital (TW)
- Taichung Hospital (TW)
- Shu-Te University (TW)
- Chung Shan Medical University (TW)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-13
- DOI
- https://doi.org/10.3389/fimmu.2025.1744226
- Primary Topic
- Autoimmune and Inflammatory Disorders Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Kaohsiung Medical University
- Kaohsiung Medical University Chung-Ho Memorial Hospital