Identification of Antihypertensive Drug Interactions with Other Drugs in Hypertension Patients at Primary Health Center, Cimahi Tengah District, Cimahi

Background: Hypertension or high blood pressure is a chronic disease characterized by persistently elevated arterial blood pressure.It typically requires long-term management with antihy-pertensive medications, such as amlodipine and captopril.Patients with hypertension of-ten also receive medications for comorbidities, such as diabetes mellitus or dyslipidemia, which may increase the risk of drug interactions.This study aimed to identify potential interactions between antihypertensive medications and other drugs used by hypertensive patients at the Primary Health Center Cimahi Tengah District, Cimahi, during the period from February to July 2023.Methods: Sampling was conducted using a purposive sampling method, with secondary data obtained from patient prescriptions that met the inclusion criteria, comprising 166 patients.Results: Based on the study findings regarding potential interactions between antihypertensive medications and other drugs, it can be concluded that most patients diagnosed with hypertension were aged 56-65 years, females, having comorbid dyslipidemia, and most commonly the one's using amlodipine as their antihypertensive medication.The most frequent potential interaction identified was between amlodip-ine with ibuprofen, primarily through a pharmacodynamic drug interaction mechanism, accounting for 167 cases (78.77%).Based on severity, most potential drug interactions were of moderate severity, with a total of 164 occurrences (77.36%).This study found that the potential drug-drug interactions were relatively common among patients with hypertension at the primary health center, with a substantial proportion categorized as moderately severe.The most frequent interaction identified was between amlodipine and ibuprofen. Conclusion:These results highlight the importance of implementing robust medication management strategies to identify and minimize potential drug interactions.