IgG/IgM-coated gut microbiota in schizophrenia: associations with inflammation disease activity

Our findings reveal that IgG/IgM-coated intestinal microbiota display distinct immunoreactive microbiota signatures associated with SCZ. These coated communities promote gut inflammation without inducing anxiety-like behavior, highlighting their potential as novel biomarkers of SCZ-associated immune dysregulation and as targets for personalized therapeutic strategies.

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Publication Details

Journal
Frontiers in Psychiatry
Published
2026-01-13
DOI
https://doi.org/10.3389/fpsyt.2025.1689069
Primary Topic
Gut microbiota and health
Type
article
Field-Weighted Citation Impact
0.00
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article

IgG/IgM-coated gut microbiota in schizophrenia: associations with inflammation disease activity

Ruibin Luo, Caihong Liu, Ruihuan Xu, Haipeng Liao et al.
Frontiers in Psychiatry
Gut microbiota and health
article

IgG/IgM-coated gut microbiota in schizophrenia: associations with inflammation disease activity

Ruibin Luo, Caihong Liu, Ruihuan Xu, Haipeng Liao, Yinmei Wang, Zhixiang Li, Yifan Li, Xi Chen, Ze Wu, Junlin Wu, Guohao Xu
article en

Abstract

Our findings reveal that IgG/IgM-coated intestinal microbiota display distinct immunoreactive microbiota signatures associated with SCZ. These coated communities promote gut inflammation without inducing anxiety-like behavior, highlighting their potential as novel biomarkers of SCZ-associated immune dysregulation and as targets for personalized therapeutic strategies.

Frontiers in PsychiatryVol. 16
Beihua University (CN), Jiaying University (CN), Longgang Central Hospital (CN), Shenzhen Chronic Disease Prevention Center (CN), Chinese University of Hong Kong, Shenzhen (CN), Dongguan People’s Hospital (CN), University of Hong Kong - Shenzhen Hospital (CN), Shenzhen Second People's Hospital (CN)
Good health and well-being
Openalex Percentile: Top 90%
Gut microbiota and health
DOIOpen Access PDFOpenAlex
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