Protein kinase C zeta promotes thyroid Cancer progression and represents a novel therapeutic target: evidence from specific atypical PKC inhibitor 2-acetyl-1,3-cyclopentanedione inhibitor studies
PKCζ activation correlates with thyroid cancer aggressiveness and drives malignant progression through EMT regulation. ACPD effectively targets PKCζ-mediated oncogenic pathways, suggesting PKCζ inhibition as a promising therapeutic strategy for aggressive thyroid cancers.
Authors
- Rongzhan Fu (ORCID: https://orcid.org/0000-0002-9281-9907)
- Jian Ding
Institutions
- Shandong University (CN)
- Shandong Provincial Hospital (CN)
- Shandong Provincial QianFoShan Hospital (CN)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2026-01-13
- DOI
- https://doi.org/10.3389/fmed.2025.1714626
- Primary Topic
- Protein Kinase Regulation and GTPase Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00