NETs drive myocardial fibrosis in hypertension via an NF-κB/ferroptosis axis

These findings identify a pathogenic NETs/NF-κB/ferroptosis axis that drives hypertensive myocardial fibrosis. NETs promote oxidative stress and iron-dependent cell death in cardiomyocytes, amplifying inflammatory and profibrotic signaling. Therapeutic targeting of NETs formation or downstream ferroptotic and NF-κB pathways may thus attenuate fibrotic remodeling and preserve cardiac function in HHD. This study provides mechanistic insight into how sterile inflammation orchestrates myocardial injury and highlights novel intervention strategies against hypertensive cardiac fibrosis.