Seasonal allergen exposure recalls IgE+ plasmablasts to reload allergic effector cells

Seasonal allergen exposure boosts the production of Immunoglobulin E (IgE) antibodies, leading to allergic diseases affecting more than 30% of the population. However, the cellular mechanisms and pathological consequences of secondary IgE production in humans remain unclear. Here, we demonstrate that IgE⁺ plasmablasts serve as the dominant cellular source responsible for the seasonal amplification of IgE. During birch pollen season, allergen exposure selectively boosts IgE production targeting pre-established conformational epitopes of the major allergen Bet v 1, with no synchronous increase in Bet v 1-specific IgG. Crucially, this plasmablast-derived IgE re-establishes allergen-specific effector cell activation that declines in absence of allergen exposure. Our findings uncover a key role of IgE⁺ plasmablasts in the rapid recall of allergic responses and highlight their potential as a therapeutic target for allergy.

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Publication Details

Journal
Immunity & Inflammation
Published
2026-01-13
DOI
https://doi.org/10.1007/s44466-025-00018-w
Primary Topic
Allergic Rhinitis and Sensitization
Type
article
Field-Weighted Citation Impact
0.00

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article

Seasonal allergen exposure recalls IgE+ plasmablasts to reload allergic effector cells

Mohammed Zghaebi, Inna Tulaeva, Daria Trifonova, Evgenii V. Smolnikov et al.
Immunity & Inflammation
Allergic Rhinitis and Sensitization
article

Seasonal allergen exposure recalls IgE+ plasmablasts to reload allergic effector cells

Mohammed Zghaebi, Inna Tulaeva, Daria Trifonova, Evgenii V. Smolnikov, Victoria Garib, Raffaela Campana, Aldine Tu, Musa Chaitovich Khaitov, Sabine Flicker, Victoria Stanek, Julia Eckl-Dorna, Tianchi Jiang, Susanne Vrtala, Alla Litovkina, Maria Byazrova, Alexander Filatov, Alfira Romanova, Veronika Skvortsova, Olga Elisyutina, Rudolf Valenta, Huey-Jy Huang
article en

Abstract

Seasonal allergen exposure boosts the production of Immunoglobulin E (IgE) antibodies, leading to allergic diseases affecting more than 30% of the population. However, the cellular mechanisms and pathological consequences of secondary IgE production in humans remain unclear. Here, we demonstrate that IgE⁺ plasmablasts serve as the dominant cellular source responsible for the seasonal amplification of IgE. During birch pollen season, allergen exposure selectively boosts IgE production targeting pre-established conformational epitopes of the major allergen Bet v 1, with no synchronous increase in Bet v 1-specific IgG. Crucially, this plasmablast-derived IgE re-establishes allergen-specific effector cell activation that declines in absence of allergen exposure. Our findings uncover a key role of IgE⁺ plasmablasts in the rapid recall of allergic responses and highlight their potential as a therapeutic target for allergy.

Immunity & InflammationVol. 2(1)
Peoples' Friendship University of Russia (RU), Sechenov University (RU), Lomonosov Moscow State University (RU), Vienna General Hospital (AT), Pirogov Russian National Research Medical University (RU), Karl Landsteiner University of Health Sciences (AT), Federal Medical-Biological Agency (RU), Medical University of Vienna (AT), Thermo Fisher Scientific (Norway) (NO)
Austrian Science Fund, Russian Science Foundation
Good health and well-being
Openalex Percentile: Top 93%
Allergic Rhinitis and Sensitization
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