LCZ696 (sacubitril/valsartan mixture) promotes cardiac repair and reverses residual remodelling of surgical ventricular reconstruction in post‐myocardial infarction mice by targeting circMap4k2/LIN28A/PDK1 pathway

LCZ696 induces glycolysis, promotes myocardial repair, and alleviates residual remodelling of SVR by targeting the circMap4k2/LIN28A/PDK1 pathway.

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Publication Details

Journal
British Journal of Pharmacology
Published
2026-01-12
DOI
https://doi.org/10.1111/bph.70320
Primary Topic
Cardiac Fibrosis and Remodeling
Type
article
Field-Weighted Citation Impact
0.00
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article

LCZ696 (sacubitril/valsartan mixture) promotes cardiac repair and reverses residual remodelling of surgical ventricular reconstruction in post‐myocardial infarction mice by targeting circMap4k2/LIN28A/PDK1 pathway

Yang DH, D. Li, Junyu Yan, Xueting Qiu
British Journal of Pharmacology
Cardiac Fibrosis and Remodeling
article

LCZ696 (sacubitril/valsartan mixture) promotes cardiac repair and reverses residual remodelling of surgical ventricular reconstruction in post‐myocardial infarction mice by targeting circMap4k2/LIN28A/PDK1 pathway

Yang DH, D. Li, Junyu Yan, Xueting Qiu
article en

Abstract

LCZ696 induces glycolysis, promotes myocardial repair, and alleviates residual remodelling of SVR by targeting the circMap4k2/LIN28A/PDK1 pathway.

British Journal of Pharmacology
Chinese Academy of Medical Sciences & Peking Union Medical College (CN), Guangdong Academy of Medical Sciences (CN), Guangdong Provincial People's Hospital (CN), Fu Wai Hospital (CN), Southern Medical University (CN)
Good health and well-being
Openalex Percentile: Top 91%
Cardiac Fibrosis and Remodeling
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