Risk factors associated with knee osteoarthritis severity and their correlation with Kellgren–Lawrence grade

In this cross-sectional study, CRP showed a strong association with KOA radiographic severity after adjusting for age, BMI, and pain scores. A numerically stronger association was observed in female patients, though this difference requires further confirmation. These findings highlight the potential role of systemic inflammation in KOA and support the further investigation of CRP as a supplementary clinical assessment tool.