Disrupted Vitamin D Metabolism in Hepatocellular Carcinoma: Free and Bioavailable 25(OH)D as Novel Biomarkers of Hepatic Reserve and Clinical Risk
Free and bioavailable vitamin D are profoundly compromised in HCC, reflecting impaired hepatic synthetic function and systemic inflammation. These fractions may serve as novel metabolic biomarkers superior to total 25(OH)D for assessing vitamin D deficiency and guiding individualized supplementation strategies in patients with liver cancer.
Authors
- Aleš Jerin (ORCID: https://orcid.org/0000-0002-6748-7082)
- Matej Rakuša (ORCID: https://orcid.org/0000-0002-8044-3527)
- Darko Siuka (ORCID: https://orcid.org/0000-0002-3686-0411)
- Martin Zaplotnik
- Saša Štupar
- Joško Osredkar (ORCID: https://orcid.org/0000-0002-1839-2415)
- Borut Štabuc
Institutions
- University of Ljubljana (SI)
- Ljubljana University Medical Centre (SI)
Publication Details
- Journal
- Molecules
- Published
- 2026-01-13
- DOI
- https://doi.org/10.3390/molecules31020273
- Primary Topic
- Vitamin D Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00