Effects of pharyngolaryngeal injury on nociceptive swallowing reflexes
Nociceptive stimuli elicit swallowing via mechanisms that are distinct from those activated by water. Reduced desensitization of capsaicin-evoked swallowing after pharyngolaryngeal injury suggests facilitation through TRPV1-dependent pathways, potentially driven by increased TRPV1 expression in petrosal/jugular-complex afferents.
Authors
- Ai Orimoto (ORCID: https://orcid.org/0000-0002-7153-9367)
- Mari Fukuzaki
- Chihiro Nakatomi (ORCID: https://orcid.org/0000-0003-2049-6624)
- Kentaro Ono (ORCID: https://orcid.org/0000-0002-8796-0199)
- Hiroka Yasuda
- Naoyuki Mitarai
- Tomoki Shimada
- Chia-Chien Hsu
Institutions
- Daiichi Sankyo (Germany) (DE)
- Kyushu Dental University (JP)
- Daiichi-Sankyo (Japan) (JP)
Publication Details
- Journal
- Journal of Oral Biosciences
- Published
- 2026-01-12
- DOI
- https://doi.org/10.1016/j.job.2026.100736
- Primary Topic
- Ion Channels and Receptors
- Type
- article
- Field-Weighted Citation Impact
- 0.00